Hydrochloric Acid → HCID 54546985, compound

HRID 1493226Notes

Reaction equation

HRID 1493226 reaction equation
Cl.[N:2]1([CH:7]([C:11]2[S:15][C:14]([C:16]([OH:18])=[O:17])=[CH:13][CH:12]=2)[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][N:4]=[CH:3]1.Cl>C(O)CCC>[CH2:11]([O:17][C:16]([C:14]1[S:15][C:11]([CH:7]([N:2]2[CH:6]=[CH:5][N:4]=[CH:3]2)[CH2:8][CH2:9][CH3:10])=[CH:12][CH:13]=1)=[O:18])[CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131716902HCID 131716902, compound

Product 1

HCID 54546985HCID 54546985, compoundYield 31.2%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

1.2 g of the acid of example 6 is dissolved in 20 ml of butanol and the solution is saturated with hydrochloric-acid gas under ice cooling. After 20 hours, it is concentrated by evaporation, distributed between potassium carbonate solution and ether and the ether phase is separated. After drying and concentration by evaporation of the solvent, it is distilled on the bulb tube. 200 mg of the title compound is obtained. Boiling point: 230° C./0.03 mbar.

Workup

  1. concentrationit is concentrated by evaporation
  2. customthe ether phase is separated
  3. customAfter drying
  4. concentrationconcentration
  5. customby evaporation of the solvent, it
  6. distillationis distilled on the bulb tube

Sources & evidence

ORD record
ord-81586131620b45c7bb3590e4995a649f
Source dataset
uspto-grants-1991_06
Patent number
US05021434

Reaction notes

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