Sodium hydride → HCID 14999102, compound

HRID 1493254Notes

Reaction equation

HRID 1493254 reaction equation
[CH3:1][CH:2]1[S:6][CH:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[NH:4][C:3]1=[O:13].Br[CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17].[H-].[Na+]>>[C:19]([O:18][C:16]([CH2:15][N:4]1[C:3](=[O:13])[CH:2]([CH3:1])[S:6][CH:5]1[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)=[O:17])([CH3:22])([CH3:21])[CH3:20]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 79177tert-Butyl bromoacetateHCID 14999088HCID 14999088, compound

Product 1

HCID 14999102HCID 14999102, compound

Procedure

According to the procedure of Example 24 the trans-isomer and the cis-isomer of the title compound were prepared by using 5-methyl-2-(3-pyridyl)thiazolidin-4-one, t-butyl bromoacetate, and sodium hydride.

Sources & evidence

ORD record
ord-c023a852799944c686257c150645b672
Source dataset
uspto-grants-1991_06
Patent number
US05021435

Reaction notes

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