反应详情

温度

20 °C

2-(3-Bromo-2-hydroxypropyl)naphtho[1,8-cd]isothiazole 1,1-dioxide (26.8 g), triethylamine (11 cc) and 4(4-fluorophenyl)piperazine (14.1 g) in toluene (280 cc) are heated at boiling point for 8 hours. The mixture is then cooled to a temperature of about 20° C. and stirring is maintained for 15 hours at this temperature. The precipitate formed is separated by filtration and washed with toluene (2 x 50 cc). The filtrate is evaporated to dryness at 40° C. under reduced pressure (20 mm Hg; 2.7 kPa). The residue obtained is purified by chromatography on a silica column, with ethyl acetate as eluant, and recrystallized from boiling acetonitrile (120 cc). 2-(3[4-(4-Fluorophenyl)-1-piperaz-invl]-2-hydroxypropyl}naphtho[1,8-cd]isothiazole 1,1-dioxide (16.2 g) is obtained, m.p. 130° C.

1. customfor 8 hours
2. temperatureis maintained for 15 hours at this temperature
3. customThe precipitate formed
4. customis separated by filtration
5. washwashed with toluene (2 x 50 cc)
6. customThe filtrate is evaporated to dryness at 40° C. under reduced pressure (20 mm Hg; 2.7 kPa)
7. customThe residue obtained
8. customis purified by chromatography on a silica column, with ethyl acetate as eluant
9. customrecrystallized