Hydrochloric Acid → Ammonium Chloride

HRID 1493333Notes

Reaction equation

HRID 1493333 reaction equation
C([NH:3][C:4]([NH:17][CH2:18][CH2:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)=[N:5][CH2:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[N:12]=[CH:13][NH:14][C:15]=1[CH3:16])#[N:2].[ClH:25]>>[Cl-:25].[NH4+:2].[ClH:25].[ClH:25].[ClH:25].[NH:23]1[CH:24]=[C:20]([CH2:19][CH2:18][NH:17][C:4]([NH:5][CH2:6][CH2:7][CH2:8][S:9][CH2:10][C:11]2[N:12]=[CH:13][NH:14][C:15]=2[CH3:16])=[NH:3])[N:21]=[CH:22]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178433665HCID 178433665, compound

Product 2

HCID 25517Ammonium ChlorideHCID 178433666HCID 178433666, compound

Procedure

0.7 g (2.02 mmol) of N-cyano-N'-2-(imidazol-4-yl)ethyl-N"-[3-[(5-methylimidazol-4-yl)methylthio]propyl]guanidine are heated under reflux in 30 ml of 18% hydrochloric acid for 6 hours and evaporated to dryness, leaving 0.98 g (100%) of a turbid oil of ammonium chloride and N-[2-(imidazol-4-yl)ethyl]-N'-[3-[(5-methylimidazol-4-yl)methylthio]propyl]guanidine trihydrochloride as residue.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-81e7a0e9c0c34f76bc1d6a6d43b0be4e
Source dataset
uspto-grants-1991_06
Patent number
US05021431

Reaction notes

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