HCID 178523905, compound → HCID 178512141, compound

Participants

Reaction Steps

0.5 g (1.2 mmol) of N-benzoyl-N'-(2-hydroxy-3-phenoxypropyl)-N"-[3-(imidazol-4-yl)propyl]-guanidine are heated under reflux in 30 ml of 20% hydrochloric acid for 6 hours. The reaction mixture is worked up by a method analogous to that of Example 4. The dihydrochloride crystallises from isopropyl alcohol/acetone in the form of colourless crystals melting at 165°-166° C.

Provenance & Evidence