HCID 178523905, compound → HCID 178512141, compound

HRID 1493337Notes

Reaction equation

HRID 1493337 reaction equation
C([NH:9][C:10]([NH:20][CH2:21][CH:22]([OH:31])[CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[N:11][CH2:12][CH2:13][CH2:14][C:15]1[N:16]=[CH:17][NH:18][CH:19]=1)(=O)C1C=CC=CC=1>Cl>[OH:31][CH:22]([CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:21][NH:20][C:10]([NH:11][CH2:12][CH2:13][CH2:14][C:15]1[N:16]=[CH:17][NH:18][CH:19]=1)=[NH:9]

Participants

3

Reactant 1

HCID 178523905HCID 178523905, compound

Product 1

HCID 178512141HCID 178512141, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.5 g (1.2 mmol) of N-benzoyl-N'-(2-hydroxy-3-phenoxypropyl)-N"-[3-(imidazol-4-yl)propyl]-guanidine are heated under reflux in 30 ml of 20% hydrochloric acid for 6 hours. The reaction mixture is worked up by a method analogous to that of Example 4. The dihydrochloride crystallises from isopropyl alcohol/acetone in the form of colourless crystals melting at 165°-166° C.

Workup

  1. customThe dihydrochloride crystallises from isopropyl alcohol/acetone in the form of colourless crystals melting at 165°-166° C.

Sources & evidence

ORD record
ord-778b2e007c464db9a1a7bf543d9e75e3
Source dataset
uspto-grants-1991_06
Patent number
US05021431

Reaction notes

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