HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Benzyl 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Benzyl 3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate | HCID 12804725 | — |
| Product | Benzyl 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate | HCID 15136299 | — |
Reaction Steps
A solution of benzyl 1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylate (26 mg) in anhydrous methanol (1 ml) at 0° C. is treated with ethereal CH2N2 until a yellow color persists. The mixture is stirred 15 more minutes in the cold and then evaporated in vacuo. Chromatography of the residue on silica gel provides benzyl 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05021566 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-1472615bbbaf405db36f8023774542f4 |
| Source note | uspto-grants-1991_06 |