1-Hydroxy-2-naphthoic acid → HCID 86744748, compound

HRID 1493709Notes

Reaction equation

HRID 1493709 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=[N:9][NH:10][C:11](=[O:15])[CH2:12][CH2:13][CH3:14])[CH3:8])=[CH:3][CH:2]=1.[OH:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][C:18]=1[C:27]([OH:29])=[O:28]>C(O)C>[OH:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][C:18]=1[C:27]([OH:29])=[O:28].[N:1]1[CH:6]=[CH:5][C:4]([C:7](=[N:9][NH:10][C:11](=[O:15])[CH2:12][CH2:13][CH3:14])[CH3:8])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 53879071HCID 53879071, compound2×

Product 1

HCID 86744748HCID 86744748, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 8.2 gm (0.04 mole) of butyric acid [1-(4-pyridinyl)ethylidene]hydrazide (Compound 144), 7.53 gm (0.04 mole) of 1-hydroxy-2-naphthoic acid and 100 ml of absolute ethanol is refluxed 7 hr. Cooling the reaction mixture to room temperature and then chilling yields a solid which is collected and dried to provide 13.67 gm (87%) of the title compound having a melting point of 158.7° C.

Workup

  1. temperatureis refluxed 7 hr
  2. temperaturechilling
  3. customyields a solid which
  4. customis collected
  5. customdried

Sources & evidence

ORD record
ord-a6c92aaf1aa04923b9b54bb2d8f923f1
Source dataset
uspto-grants-1991_06
Patent number
US05023334

Reaction notes

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