HCID 15661459, compound → HCID 15661460, compound

HRID 1493856Notes

Reaction equation

HRID 1493856 reaction equation
O1CCCCC1[O:7][CH2:8][C:9]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]=2[CH:12]=[C:11]([C:23]([CH3:25])=[O:24])[CH:10]=1>OS(O)(=O)=O.C([O-])(O)=O.[Na+]>[OH:7][CH2:8][C:9]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]=2[CH:12]=[C:11]([C:23]([CH3:25])=[O:24])[CH:10]=1

Participants

4

Reactant 1

HCID 15661459HCID 15661459, compound

Product 1

HCID 15661460HCID 15661460, compoundYield 91.4%

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidSolventHCID 516892Sodium BicarbonateSolvent

Procedure

1-(2-Tetrahydropyranyl)oxymethyl-3-methylcarbonyl-9-fluorenone (197 mg) was dissolved in 1% H2SO4 (5 ml) and allowed to stand at room temperature for 0.5 hour. The reaction mixture was diluted with excess NaHCO3 soln (10%). The MeOH was removed under reduced pressure and the residue was extracted with EtOAc, dried and evaporated gave the product (135 mg).

Workup

  1. customThe MeOH was removed under reduced pressure
  2. extractionthe residue was extracted with EtOAc
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-c79fab4c779042f3b230496a9e023cea
Source dataset
uspto-grants-1991_06
Patent number
US05025007

Reaction notes

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