反应详情

In 9 ml of pyridine was dissolved 5.0 g (8.52 mmole) of 3-O-octadecyl-1-O-tritylglycerol, and after 1.95 g (10.22 mmole) of tosyl chloride was added to the solution, the mixture was stirred at room temperature overnight and concentrated to dryness under reduced pressure. The residue was dissolved in 50 ml of water and 50 ml of dichloromethane, and after shaking thoroughly, the dichloromethane layer was separated out. The organic layer was concentrated to dryness under reduced pressure, and the residue was purified by silica gel column (50 g), with n-hexane.ethyl acetate (193:7) used as an eluent, to give 5.3 g (yield of 83.9%) of colorless needles.

1. concentrationconcentrated to dryness under reduced pressure
2. dissolutionThe residue was dissolved in 50 ml of water
3. stirring50 ml of dichloromethane, and after shaking thoroughly
4. customthe dichloromethane layer was separated out
5. concentrationThe organic layer was concentrated to dryness under reduced pressure
6. customthe residue was purified by silica gel column (50 g), with n-hexane