Water → HCID 178481592, Verbindung

HRID 1493925Notizen

Reaktionsgleichung

[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH3:9])[C:3]=1[NH2:10].N[C:12](N)=O.[OH2:15]>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[C:3]=1[N:10]=[C:9]([OH:15])[N:8]2[CH3:12]

Komponenten

Edukt 3

HCID 962Water

HCID 1176Urea

HCID 3084776-chloro-N4-methylpyrimidine-4,5-diamine

Produkt 1

HCID 178481592HCID 178481592, VerbindungAusbeute 60 %

Reaktionsbedingungen

Temperatur: 180 °C

Versuchsvorschrift

A mixture of 4.76 parts of 6-chloro-N4 methyl-4,5-pyrimidinediamine and 7.2 parts of urea was stirred and heated for 1 hour at 180° C. After cooling, the residue was suspended in water. The product was filtered off and dried, yielding 3.3 parts (60%) of 6-chloro-9-methyl-9H-purin-8-ol (intermediate 174).

Aufarbeitung

temperatureAfter cooling
filtrationThe product was filtered off
customdried

Quellen und Nachweise

ORD-Eintrag: ord-384f3583ef4940e4a7b7d17dd677c80c
Quelldatensatz: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05025014

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