Methane → HCID 19108674, compound

HRID 1493986Notes

Reaction equation

HRID 1493986 reaction equation
[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[CH3:6][O:7][C:8]1[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=1[O:10][CH2:11][CH2:12][OH:13].C>C(Cl)Cl>[CH3:6][O:7][C:8]1[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=1[O:10][CH2:11][CH2:12][O:13][S:1](=[O:4])(=[O:3])[NH2:2]

Participants

5

Reactant 3

HCID 297MethaneHCID 24499Chlorosulfamic acidHCID 38041392-(2-methoxyphenoxy)ethanol

Product 1

HCID 19108674HCID 19108674, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by the procedure of Example 16 from sulfamoyl chloride and 2-(2-methoxyphenoxy)ethanol. The solid obtained was dissolved in 150 ml of methylene chloride, and the solution was treated with charcoal and filtered through Celite®. The filtrate was evaporated under reduced pressure and the solid residue was recrystallized from methylene chloride-petroleum ether (30°-60° C.) to give the title compound in 25% yield as a white solid, mp 102°-104° C.

Workup

  1. customThe solid obtained
  2. filtrationfiltered through Celite®
  3. customThe filtrate was evaporated under reduced pressure
  4. customthe solid residue was recrystallized from methylene chloride-petroleum ether (30°-60° C.)

Sources & evidence

ORD record
ord-f76839b3291744728d4cddb16ef19cf9
Source dataset
uspto-grants-1991_06
Patent number
US05025031

Reaction notes

Loading…