2-Phenoxy-1-propanol → 2-Phenoxypropanol sulfamate

HRID 1493987Notes

Reaction equation

HRID 1493987 reaction equation
[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[O:6]([CH:13]([CH3:16])[CH2:14][OH:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[O:6]([CH:13]([CH3:16])[CH2:14][O:15][S:1](=[O:4])(=[O:3])[NH2:2])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 201292-Phenoxy-1-propanolHCID 24499Chlorosulfamic acid

Product 1

HCID 191086852-Phenoxypropanol sulfamate

Procedure

The title compound was prepared by procedures of Example 16 from sulfamoyl chloride and 2-phenoxypropanol. The oil obtained was further purified by chromatography (silica gel, eluted with methylene chloride) and recrystallization to give the title compound as a colorless, viscous oil in 35% yield.

Workup

  1. customThe oil obtained
  2. customwas further purified by chromatography (silica gel, eluted with methylene chloride) and recrystallization

Sources & evidence

ORD record
ord-49b84d7750004e6d8ebe2201632d38d3
Source dataset
uspto-grants-1991_06
Patent number
US05025031

Reaction notes

Loading…