反应详情

A solution of 0.174 g of methyl 8-(p-chlorophenylsulfonamido)-4-(2-hydroxyethyl)octanoate in 2 mL methylene chloride is cooled to 0° C. and 0.1 mL of triethylamine is added followed by 0.042 mL of methanesulfonyl chloride. After 1 hour, the reaction is washed with saturated sodium bicaronate and the organic layer is dried, filtered and evaporated to yield methyl 8-(p-chlorophenylsulfonamido)-4-(2-methanesulfonyloxyethyl)-octanoate as an oil.

1. washthe reaction is washed with saturated sodium bicaronate
2. customthe organic layer is dried
3. filtrationfiltered
4. customevaporated