Methyl iodide → HCID 15679990, compound

HRID 1494173Notes

Reaction equation

HRID 1494173 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([O:9][CH2:10][O:11][C:12]([N:14]([CH2:16][CH2:17][CH2:18][N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[CH2:23][CH2:22][C:21]3[CH:30]=[CH:31][CH:32]=[CH:33][C:20]2=3)[CH3:15])=[O:13])=[O:8])[CH:2]=1.[CH3:34][I:35]>[N+](C)([O-])=O>[I-:35].[CH:30]1[C:21]2[CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[N:19]([CH2:18][CH2:17][CH2:16][N:14]([C:12]([O:11][CH2:10][O:9][C:7]([C:3]3[CH:2]=[N+:1]([CH3:34])[CH:6]=[CH:5][CH:4]=3)=[O:8])=[O:13])[CH3:15])[C:20]=2[CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 15679988HCID 15679988, compound

Product 1

HCID 15679990HCID 15679990, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

Eight-tenths gram (0.0018 mol) of the product of Example 52 in 30 mL of nitromethane was methylated with 0.8 mL of methyl iodide at 25°-30° C. for 48 hours. The solvent was removed in vacuo and the residue was slurried with ethyl ether, filtered and dried over P2O5. The quaternary salt was obtained in 83% yield (0.88 g) as a light yellow solid melting at 172°-175° C. (dec.) and having the structural formula: ##STR94##

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered
  3. dry with materialdried over P2O5

Sources & evidence

ORD record
ord-82c9de7940bc4a79b4d1e19b47348a9a
Source dataset
uspto-grants-1991_06
Patent number
US05024998

Reaction notes

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