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HRID 1494192Notes

Reaction equation

HRID 1494192 reaction equation
N1C=CC=C([C:7]([C@@:9]2([OH:34])[C@@H:13]([CH:14]([C:16](=[O:21])[C:17]([CH3:20])([CH3:19])[CH3:18])[OH:15])[O:12][C@@H:11]([N:22]3[CH:33]=[C:28]([C:29]([F:32])([F:31])[F:30])[C:26](=[O:27])[NH:25][C:23]3=[O:24])[CH2:10]2)=[O:8])C=1.C[I:36].[CH3:37][C:38]([CH3:40])=O>>[I-:36].[CH3:23][N:22]1[CH:11]=[CH:10][CH:40]=[CH2+:38][CH:37]1[C:7]([C@@:9]1([OH:34])[C@@H:13]([CH:14]([C:16](=[O:21])[C:17]([CH3:20])([CH3:18])[CH3:19])[OH:15])[O:12][C@@H:11]([N:22]2[CH:33]=[C:28]([C:29]([F:31])([F:32])[F:30])[C:26](=[O:27])[NH:25][C:23]2=[O:24])[CH2:10]1)=[O:8]

Participants

3

Reactant 3

HCID 180AcetoneHCID 6328Methyl iodideHCID 1317167533'-(3-Pyridylcarbonyl)-5'-pivaloyltrifluorothymidine

Product 0

No Product data yet.

Procedure

To 440 mg of the product of Example 105 dissolved in 10 mL of acetone, 1.0 g of methyl iodide was added. The mixture was refluxed for 10 hours, then the precipitate which formed was collected by suction filtration to give 550 mg of the desired product as yellow leaves melting at 188°-190° C. with decomposition. NMR analysis confirmed that the product had the structural formula: ##STR134##

Workup

  1. temperatureThe mixture was refluxed for 10 hours
  2. customthe precipitate which formed
  3. filtrationwas collected by suction filtration

Sources & evidence

ORD record
ord-8b4743bfdd88427198b3d32a9a9f10cd
Source dataset
uspto-grants-1991_06
Patent number
US05024998

Reaction notes

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