Methyl iodide →

HRID 1494201Notes

Reaction equation

HRID 1494201 reaction equation
[Cl:1][CH2:2][CH2:3][N:4]([N:19]=[O:20])[C:5]([NH:7][CH2:8][CH2:9][O:10]C(C1C=NC=CC=1)=O)=[O:6].C[I:22].[O:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>>[I-:22].[Cl:1][CH2:2][CH2:3][N:4]([N:19]=[O:20])[C:5]([NH:7][CH2:8][CH2:9][O:10][C:27]([CH:26]1[CH2+:25]=[CH:24][CH:2]=[CH:3][N:4]1[CH3:5])=[O:23])=[O:6]

Participants

3

Reactant 3

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 15680044N-(2-Chloroethyl)-N'-[2-(3-pyridinecarbonyloxy)ethyl]-N-nitrosourea

Product 0

No Product data yet.

Conditions

Temperature
50 °C

Procedure

A solution of the product of Example 122 (1.5 g, 5 mmol) in 40 mL of tetrahydrofuran was treated with excess methyl iodide. The mixture was stirred at 50° C. for 4 hours. The finely crystalline, yellow solid thus obtained (1.8 g, 82%) melted at 120°-121° C. and had the structure ##STR151## as confirmed by elemental analysis.

Workup

  1. customThe finely crystalline, yellow solid thus obtained (1.8 g, 82%) melted at 120°-121° C.

Sources & evidence

ORD record
ord-21023d6e175640c28c0d8695d3522898
Source dataset
uspto-grants-1991_06
Patent number
US05024998

Reaction notes

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