Methyl iodide →

HRID 1494203Notes

Reaction equation

HRID 1494203 reaction equation
[F:1][CH2:2][CH2:3][N:4]([N:19]=[O:20])[C:5]([NH:7][CH2:8][CH2:9][O:10]C(C1C=NC=CC=1)=O)=[O:6].C[I:22].[O:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>>[I-:22].[F:1][CH2:2][CH2:3][N:4]([N:19]=[O:20])[C:5]([NH:7][CH2:8][CH2:9][O:10][C:27]([CH:26]1[CH2+:25]=[CH:24][CH:2]=[CH:3][N:4]1[CH3:5])=[O:23])=[O:6]

Participants

3

Reactant 3

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 15680048N-(2-Fluoroethyl)-N'-[2-(3-pyridinecarbonyloxy)ethyl]-N-nitrosourea

Product 0

No Product data yet.

Conditions

Temperature
50 °C

Procedure

A solution of the product of Example 125 (1.56 g, 5.4 mmol) in 40 mL of tetrahydrofuran was treated with excess methyl iodide. The mixture was stirred at 50° C. for 4 hours. The finely crystalline, yellow solid thus obtained (2.20 g, 94.1%) melted at 123°-125° C. and had the structural formula ##STR154##

Workup

  1. customThe finely crystalline, yellow solid thus obtained (2.20 g, 94.1%) melted at 123°-125° C.

Sources & evidence

ORD record
ord-6d3750ce27214d56bbcbc1c417aa2e97
Source dataset
uspto-grants-1991_06
Patent number
US05024998

Reaction notes

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