HRID1494234

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID75077

Methyl Gentisate

C8H8O4

结构：ICCCCCCc1cccc(OCc2ccccc2)c1OCc1ccccc1

HCID14986285

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cc(OCCCCCCc2cccc(OCc3ccccc3)c2OCc2ccccc2)ccc1O

HCID14986341

未命名化合物

收率 39%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 1.00 g of 1-(6-iodohexyl)-2,3-bis(phenylmethoxy)benzene, 0.34 g of 2,5-dihydroxybenzoic acid methyl ester and 1.0 g of potassium carbonate in 30 mL of acetone was stirred at reflux for 17 hours. Workup as in Example 16 and chromatography on 60 g of silica gel using 1% ethyl acetate-toluene gave 0.42 g (39% yield) of 2-hydroxy-5-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid methyl ester as an oil.

WORKUP

后处理

temperatureat reflux for 17 hours

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-140d0631289940a48d00e2df498ac064
来源数据集: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05025036
来源说明: uspto-grants-1991_06

反应 SMILES

I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[CH3:30][O:31][C:32](=[O:41])[C:33]1[CH:38]=[C:37]([OH:39])[CH:36]=[CH:35][C:34]=1[OH:40].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:30][O:31][C:32](=[O:41])[C:33]1[CH:38]=[C:37]([O:39][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:9]=2[O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:36]=[CH:35][C:34]=1[OH:40]