Acetic Acid → HCID 19827430, compound

HRID 1494284Notes

Reaction equation

HRID 1494284 reaction equation
[N+:1]([C:4]1[C:5]([NH2:14])=[C:6]([OH:13])[CH:7]=[CH:8][C:9]=1CCBr)([O-:3])=[O:2].[CH3:15][NH:16][CH3:17].O.[C:19](O)(=O)[CH3:20]>>[N+:1]([C:4]1[C:5]([NH:14][CH2:19][CH3:20])=[C:6]([OH:13])[CH:7]=[CH:8][C:9]=1[N:16]([CH3:17])[CH3:15])([O-:3])=[O:2]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 674DimethylamineHCID 962WaterHCID 19827420HCID 19827420, compound

Product 1

HCID 19827430HCID 19827430, compound

Procedure

0.0766 mol (20 g) of 3-nitro-4-(β-bromoethyl)-aminophenol is heated for 20 minutes, at 60° C., in 60 ml of a 40% strength aqueous solution of dimethylamine. The reaction medium is poured into 300 ml of iced water and then neutralised with acetic acid. The expected product precipitates. It is filtered off, washed with water and recrystallised from ethanol. After drying in vacuo, it melts at 151° C.

Workup

  1. customThe expected product precipitates
  2. filtrationIt is filtered off
  3. washwashed with water
  4. customrecrystallised from ethanol
  5. customAfter drying in vacuo, it melts at 151° C.

Sources & evidence

ORD record
ord-ea0a4193d0a14e18a27f8ae10c37e822
Source dataset
uspto-grants-1991_06
Patent number
US05026401

Reaction notes

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