反应详情

0.109 mol (28.4 g) of 2-acetylamino-4-aminophenyl β-hydroxypropyl ether monohydrochloride is dissolved, under reflux, in a mixture of 80 ml of ethanol saturated with hydrogen chloride and 25 ml of 36% strength hydrochloric acid. The reaction mixture is heated under reflux for 11/2 hours. On cooling, the expected product precipitates in the form of the dihydrochloride. The product is filtered off, washed with a small amount of absolute alcohol and dried in vacuo at 50° C. It melts with decomposition at between 215° and 220° C.

1. temperatureThe reaction mixture is heated
2. temperatureunder reflux for 11/2 hours
3. temperatureOn cooling
4. customthe expected product precipitates in the form of the dihydrochloride
5. filtrationThe product is filtered off
6. washwashed with a small amount of absolute alcohol
7. customdried in vacuo at 50° C
8. custommelts with decomposition at between 215° and 220° C.