Potassium Carbonate → HCID 19827484, compound

HRID 1494292Notes

Reaction equation

HRID 1494292 reaction equation
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]([C:18]1[CH:19]=[N:20][CH:21]=[N:22][CH:23]=1)([CH:15]([CH3:17])[CH3:16])[C:9]#[C:10][Si](C)(C)C>CO>[OH:7][C:8]([C:18]1[CH:23]=[N:22][CH:21]=[N:20][CH:19]=1)([CH:15]([CH3:17])[CH3:16])[C:9]#[CH:10]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 19827489HCID 19827489, compound

Product 1

HCID 19827484HCID 19827484, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Potassium carbonate (4 g) was added to the product of stage 1 (19.5 g, 0.11 mol) in methanol (100 ml) and the mixture was stirred for 3.3 hours. The mixture was then partitioned between ether and water. The ether layer was separated, dried over sodium sulphate, and concentrated under reduced pressure to give the title compound as an almost colourless solid (11.2 g). The product was further purified by recrystallisation from hexane to give a solid of melting point 112.4° C.

Workup

  1. customThe mixture was then partitioned between ether and water
  2. customThe ether layer was separated
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-d658961172194bfd88127f5e7dba7c91
Source dataset
uspto-grants-1991_06
Patent number
US05026418

Reaction notes

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