Lithium Hydroxide → HCID 9859706, compound

HRID 1494298Notes

Reaction equation

HRID 1494298 reaction equation
C[O:2][C:3]([CH2:5][O:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=[C:9]([C:17]([O:19]C)=[O:18])[CH:8]=1)=[O:4].[Li+].[OH-]>O.CO>[C:3]([CH2:5][O:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=[C:9]([C:17]([OH:19])=[O:18])[CH:8]=1)([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 15166953HCID 15166953, compound

Product 1

HCID 9859706HCID 9859706, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

A sample of methyl 4-methoxycarbonylmethyloxy-2-quinolinecarboxylate(0.20 g, 0.00073 mole) prepared as in Example II, was hydrolyzed by the addition of lM LiOH (2.2 ml, 0.0022 mole) in H2O/MeOH. After stirring for 18 hours, the MeOH was evaporated, the product dissolved in H2O, and acidified to pH 2.6 with lN HCl thereby precipitating a white solid. A yield of 0.15 g (83%) of 4-carboxymethyloxy-2-quinolinecarboxylic acid was obtained after filtering and drying in a vacuum dessicator. Melting point was 240° C. (dec.).

Workup

  1. customthe MeOH was evaporated
  2. dissolutionthe product dissolved in H2O
  3. customthereby precipitating a white solid

Sources & evidence

ORD record
ord-97c893311d5742dab3df0aafb055fee4
Source dataset
uspto-grants-1991_06
Patent number
US05026700

Reaction notes

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