Lithium Hydroxide → HCID 178524592, compound

HRID 1494301Notes

Reaction equation

HRID 1494301 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]C)=[O:9])[N:5]=[C:4]2[CH:12]=[CH:13][S:14][C:3]=12.[Li+].[OH-]>>[OH:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[N:5]=[C:4]2[CH:12]=[CH:13][S:14][C:3]=12

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 178498533HCID 178498533, compound

Product 1

HCID 178524592HCID 178524592, compound

Procedure

A sample of methyl 7-hydroxythieno[3,2-b]pyridine-5-carboxylate is hydrolyzed by the addition of 2.5 equivalents of aqueous lM LiOH and stirred for 16 hours at RT. The aqueous reaction mixture is extracted 2x with ethyl acetate and acidified to pH 2.0 with aqueous lN HCl. The resulting precipitate is filtered, washed with water and dried to afford 7-hydroxythieno[3,2,b]pyridine-5-carboxylic acid.

Workup

  1. extractionThe aqueous reaction mixture is extracted 2x with ethyl acetate
  2. filtrationThe resulting precipitate is filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-f507924a7c2645e9ad9ebd1bb5a93526
Source dataset
uspto-grants-1991_06
Patent number
US05026700

Reaction notes

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