Lithium Hydroxide → HCID 178524591, compound

HRID 1494302Notes

Reaction equation

HRID 1494302 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]C)=[O:9])[N:5]=[C:4]2[S:12][CH:13]=[CH:14][C:3]=12.[Li+].[OH-]>>[OH:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[N:5]=[C:4]2[S:12][CH:13]=[CH:14][C:3]=12

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 178498524HCID 178498524, compound

Product 1

HCID 178524591HCID 178524591, compound

Procedure

A sample of methyl 4-hydroxythieno[2,3-b]pyridine-6- carboxylate is hydrolyzed by the addition of 2.5 equivalent of aqueous lM LiOH and stirred for 16 hours at RT. The aqueous reaction mixture is extracted 2x with ethyl acetate and acidified to pH 2.0 with aqueous lN HCl. The resulting precipitate is filtered, washed with water and dried to give 4-hydroxythieno[2,3-b]pyridine-6-carboxylic acid.

Workup

  1. extractionThe aqueous reaction mixture is extracted 2x with ethyl acetate
  2. filtrationThe resulting precipitate is filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-5aa2e968fb954a35b75cfbc997d15cfd
Source dataset
uspto-grants-1991_06
Patent number
US05026700

Reaction notes

Loading…