Bromine → 2-Bromo-1-(5-bromopyridin-3-yl)ethan-1-one--hydrogen bromide (1/1)

HRID 1494307Notes

Reaction equation

HRID 1494307 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[N:6][CH:7]=1.[Br:11]Br>C(Cl)(Cl)Cl.C(O)(=O)C.Br>[BrH:1].[Br:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH2:9][Br:11])[CH:5]=[N:6][CH:7]=1

Participants

5

Reactant 2

HCID 24408BromineHCID 8204233-Acetyl-5-bromopyridine

Product 1

HCID 145788482-Bromo-1-(5-bromopyridin-3-yl)ethan-1-one--hydrogen bromide (1/1)

Reagents, catalysts & solvents 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidCatalystHCID 6212ChloroformSolvent2×

Procedure

4 g (0.02 mol) of 5-bromo-3-acetyl-pyridine are dissolved in 50 ml of chloroform, 5 drops of glacial acetic acid/hydrobromic acid (35%) are added and the mixture is heated to boiling. To this boiling solution, 3.2 g (0.02 mol) of bromine in 30 ml of chloroform are added dropwise over a period of 5 hours with stirring. After cooling to ambient temperature the yellow solid product is suction filtered.

Workup

  1. temperaturethe mixture is heated to boiling
  2. filtrationfiltered

Sources & evidence

ORD record
ord-9ab989b9ea0641108e238500e902d3da
Source dataset
uspto-grants-1991_06
Patent number
US05026702

Reaction notes

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