HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 2-Bromo-1-(5-bromopyridin-3-yl)ethan-1-one--hydrogen bromide (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-Acetyl-5-bromopyridine | HCID 820423 | — |
| Catalyst | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Bromo-1-(5-bromopyridin-3-yl)ethan-1-one--hydrogen bromide (1/1) | HCID 14578848 | — |
Reaction Steps
4 g (0.02 mol) of 5-bromo-3-acetyl-pyridine are dissolved in 50 ml of chloroform, 5 drops of glacial acetic acid/hydrobromic acid (35%) are added and the mixture is heated to boiling. To this boiling solution, 3.2 g (0.02 mol) of bromine in 30 ml of chloroform are added dropwise over a period of 5 hours with stirring. After cooling to ambient temperature the yellow solid product is suction filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026702 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-9ab989b9ea0641108e238500e902d3da |
| Source note | uspto-grants-1991_06 |