Acetyl chloride → HCID 54298681, compound

HRID 1494317Notes

Reaction equation

HRID 1494317 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][CH:6]1[C:11]([C:12]2[CH:26]=[CH:25][C:15]3[N:16]=[C:17]([C:19]4[O:20][C:21]([NH2:24])=[CH:22][CH:23]=4)[NH:18][C:14]=3[CH:13]=2)=[N:10][NH:9][C:8](=[O:27])[CH2:7]1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:5][CH:6]1[C:11]([C:12]2[CH:26]=[CH:25][C:15]3[N:16]=[C:17]([C:19]4[O:20][C:21]([NH:24][C:1](=[O:3])[CH3:2])=[CH:22][CH:23]=4)[NH:18][C:14]=3[CH:13]=2)=[N:10][NH:9][C:8](=[O:27])[CH2:7]1

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 67926747HCID 67926747, compound

Product 1

HCID 54298681HCID 54298681, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

0.3 ml of acetyl chloride in 3 ml of chloroform is added to a solution of 309 mg of 5-methyl-6-[2-(5-amino-2-furyl)-5-benzimidazolyl]-4,5-dihydropyridazin-3-one and 0.2 ml of triethylamine in 10 ml of chloroform, and the mixture is boiled for 3 hours. The usual working up is carried out, and 5-methyl-6-[2-(5-acetamido-2-furyl)-5-benzimidazolyl]-4,5-dihydropyridazin-3-one is obtained.

Sources & evidence

ORD record
ord-47bbda3c5a6444538bda8c561fda1bff
Source dataset
uspto-grants-1991_06
Patent number
US05026705

Reaction notes

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