Hydrogen Bromide → HCID 67828759, compound

HRID 1494401Notes

Reaction equation

HRID 1494401 reaction equation
Cl.Cl.[N:3]1([CH:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:19]C)[CH:15]=3)[CH2:10]2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.[BrH:21]>>[BrH:21].[BrH:21].[N:3]1([CH:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:19])[CH:15]=3)[CH2:10]2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 67828769HCID 67828769, compound

Product 1

HCID 67828759HCID 67828759, compound

Procedure

The product from Example 29 (0.30 g) and 48% hydrobromic acid (12 ml) were warmed for 3 hours and heated at reflux with stirring under nitrogen for 2.5 hours. The reaction mixture was evaporated to dryness, and the residue, in ethanol, was heated on a steam bath. After standing at room temperature for two days, the mixture was filtered, and the solid was dried to obtain 0.37 g of the title compound, m.p. 192°-194° C.

Workup

  1. temperatureheated
  2. temperatureat reflux
  3. customThe reaction mixture was evaporated to dryness
  4. temperaturethe residue, in ethanol, was heated on a steam bath
  5. waitAfter standing at room temperature for two days
  6. filtrationthe mixture was filtered
  7. customthe solid was dried

Sources & evidence

ORD record
ord-480f153c77cb4f1b9659b364c2fb0b74
Source dataset
uspto-grants-1991_06
Patent number
US05026707

Reaction notes

Loading…