HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1494437Generated: October 26, 2026
Thiophenol → 1-Propanone, 2-methyl-1-phenyl-2-(phenylthio)-
https://huagongshe.com/reaction/1494437
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Propanone, 2-chloro-2-methyl-1-phenyl- | HCID 81985 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Propanone, 2-methyl-1-phenyl-2-(phenylthio)- | HCID 12270589 | — |
Reaction Steps
10.88 g of a 50% suspension of sodium hydride in paraffin mineral oil are fed into 100 ml of DMF, followed slowly by 25.11 g of thiophenol. When dissolution is complete (65° C.), the solution is cooled to 2° C. and 36.5 g of 2-chloro-2-methylpropiophenone are fed in over 30 minutes maintaining the temperature below 10° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05026740 |
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| Source dataset | uspto-grants-1991_06 |
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| ORD ID | ord-5752ad7ba6814d479c4aac8bf2293d7c |
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| Source note | uspto-grants-1991_06 |
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