Acetic Acid → 2-Phenylsulphinyl-2-methylpropiophenone

HRID 1494438Notes

Reaction equation

HRID 1494438 reaction equation
[C:1]1([S:7][C:8]([CH3:18])([CH3:17])[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(=[O:21])C.C(OC(=O)C)(=O)C.OO>C(OCC)C>[C:1]1([S:7]([C:8]([CH3:18])([CH3:17])[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[O:21])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 7918Acetic AnhydrideHCID 122705891-Propanone, 2-methyl-1-phenyl-2-(phenylthio)-

Product 1

HCID 198282132-Phenylsulphinyl-2-methylpropiophenone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

68 g of 2-phenylthio-2-methylpropiophenone (1a) are added at 0° C. to a solution prepared from 500 ml of glacial acetic acid, 47 g of acetic anhydride and 45.5 g of 33% hydrogen peroxide. After 48 hours of agitation at ambient temperature, it is taken up in ethyl ether, washed with water and neutralised with sodium bicarbonate.

Workup

  1. washwashed with water and neutralised with sodium bicarbonate

Sources & evidence

ORD record
ord-4dacfe2cae334f849ea1032cfdb59669
Source dataset
uspto-grants-1991_06
Patent number
US05026740

Reaction notes

Loading…