Methyl 3-mercaptopropionate → HCID 23173708, compound

HRID 1494441Notes

Reaction equation

HRID 1494441 reaction equation
[CH:1]1([O:7][N:8]2[C:13]([CH3:15])([CH3:14])[CH2:12][CH:11]([OH:16])[CH2:10][C:9]2([CH3:18])[CH3:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2-].[Li+].[SH:21][CH2:22][CH2:23][C:24](OC)=[O:25]>C1(C)C=CC=CC=1>[SH:21][CH2:22][CH2:23][C:24]([O:16][CH:11]1[CH2:10][C:9]([CH3:18])([CH3:17])[N:8]([O:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:13]([CH3:14])([CH3:15])[CH2:12]1)=[O:25]

Participants

5

Reactant 3

HCID 18050Methyl 3-mercaptopropionateHCID 24532Lithium amideHCID 113228111-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol

Product 1

HCID 23173708HCID 23173708, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The general procedure of Example 1 is followed using 2.00 grams (7.8 mmol) of 1-cyclohexyloxy-4-hydroxy-2,2,6,6-tetramethylpiperidine, 0.18 gram of lithium amide and 0.94 gram (7.8 mmol) of methyl 3-mercaptopropionate in 50 ml of toluene to afford the title compound after purification by silical gel chromatography.

Sources & evidence

ORD record
ord-e6d441c05e634b8ca3527c1b42154c26
Source dataset
uspto-grants-1991_06
Patent number
US05026750

Reaction notes

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