Hydrochloric Acid → HCID 178455067, compound

HRID 1494467Notes

Reaction equation

HRID 1494467 reaction equation
[CH2:1]([C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]=1[O:14][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16])[CH:2]=[CH2:3].[NH2:22][C:23]([NH2:25])=[S:24].C(O)C.[ClH:29]>O>[ClH:29].[Si:15]([O:14][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:12]=[CH:13][C:4]=1[CH2:1][CH2:2][CH2:3][NH:25][C:23](=[NH:22])[SH:24])([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:16])[CH3:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 2723790ThioureaHCID 15617924HCID 15617924, compound

Product 1

HCID 178455067HCID 178455067, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of the product of Example 122 Part C (1.55 g, 0.004 mole), thiourea (0.31 g, 0.004 mole), and absolute ethanol (8.0 mL) was heated at reflux for 7 hours. The cooled solution was treated with water (5.0 mL), cooled to 0°, and treated with concentrated hydrochloric acid (5.0 mL). The precipitated solid was isolated by filtration, rinsed with water and air-dried to provide the title compound (1.45 g, 86%) as a white powder, mp 190°-194°.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 7 hours
  3. temperaturecooled to 0°
  4. customThe precipitated solid was isolated by filtration
  5. washrinsed with water
  6. customair-dried

Sources & evidence

ORD record
ord-74be1440e71f41218536c80a1ed5c1e8
Source dataset
uspto-grants-1991_06
Patent number
US05026759

Reaction notes

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