2-(2-(2-Chloroethoxy)ethoxy)ethanol → 2-{2-[2-(2-Hydroxyethoxy)ethoxy]ethyl}-1H-isoindole-1,3(2H)-dione

HRID 1494590Notes

Reaction equation

HRID 1494590 reaction equation
Cl[CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[C:11]1(=[O:21])[NH:15][C:14](=[O:16])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12.[K]>CN(C)C=O>[C:11]1(=[O:21])[N:15]([CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10])[C:14](=[O:16])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12

Participants

4

Reactant 2

HCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanolHCID 24194345Phthalimide potassium salt

Product 1

HCID 111501572-{2-[2-(2-Hydroxyethoxy)ethoxy]ethyl}-1H-isoindole-1,3(2H)-dione

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

188 g of 2-[2-(2-Chloroethoxy)ethoxy]ethanol and 146 g of potassium phtalimide in 700 ml of dimethylformamide are brought to 95° C. for 17 hours.

Sources & evidence

ORD record
ord-281eb2a687be47b9a22fea0bb7fb3b04
Source dataset
uspto-grants-1991_06
Patent number
US05026863

Reaction notes

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