Diethyl Ether → HCID 19828704, compound

HRID 1494597Notes

Reaction equation

HRID 1494597 reaction equation
C([C:4]1([C:13]#[N:14])[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5]1)(=O)C.[Br:15]Br.[CH2:17]([O:19]CC)[CH3:18]>[Cl-].[Al+3].[Cl-].[Cl-]>[Br:15][CH2:18][C:17]([CH:12]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH:4]1[C:13]#[N:14])=[O:19]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 24408Bromine2×HCID 19828697HCID 19828697, compound

Product 1

HCID 19828704HCID 19828704, compound

Reagents, catalysts & solvents 1

HCID 6451240Aluminum(III) ChlorideCatalyst

Procedure

2-Acetyl-2,3-dihydro-1H-indene-2-carbonitrile (32.9 g) was dissolved in diethyl ether (33 ml). Aluminium chloride (0.17 g) was added. Bromine (28.4 g) was added dropwise at room temperature and the disappearance of the bromine colour was observed. The ether solution was washed with a Na2CO3 -solution and with water, dried over MgSO4, and evaporated. 35.7 g of crude product was obtained.

Workup

  1. washThe ether solution was washed with a Na2CO3 -solution and with water
  2. dry with materialdried over MgSO4
  3. customevaporated

Sources & evidence

ORD record
ord-3efc1499b880408fa50348fc819f11be
Source dataset
uspto-grants-1991_06
Patent number
US05026868

Reaction notes

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