2,4-Diamino-6-[2-(4-carboxyphenyl)prop-1-enyl]pyrido[2,3-d]pyrimidine → HCID 178508854, compound

HRID 1494610Notes

Reaction equation

HRID 1494610 reaction equation
NC1N=C(N)C2C=C(C=C(C3C=CC(C(O)=O)=CC=3)C)C=NC=2N=1.[NH2:25][C:26]1[N:27]=[C:28]([OH:48])[C:29]2[CH:35]=[C:34]([CH:36]=[C:37]([C:39]3[CH:44]=[CH:43][C:42]([C:45]([OH:47])=[O:46])=[CH:41][CH:40]=3)C)[CH:33]=[N:32][C:30]=2[N:31]=1>>[NH2:25][C:26]1[N:27]=[C:28]([OH:48])[C:29]2[CH:35]=[C:34]([CH:36]=[CH:37][C:39]3[CH:44]=[CH:43][C:42]([C:45]([OH:47])=[O:46])=[CH:41][CH:40]=3)[CH:33]=[N:32][C:30]=2[N:31]=1

Participants

3

Reactant 2

HCID 538775492,4-Diamino-6-[2-(4-carboxyphenyl)prop-1-enyl]pyrido[2,3-d]pyrimidineHCID 178439558HCID 178439558, compound

Product 1

HCID 178508854HCID 178508854, compound

Procedure

In a similar fashion, 2,4-diamino-6-[2-(4-carboxyphenyl)prop-1-enyl]pyrido[2,3-d]pyrimidine is converted to 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)prop-1-enyl]pyrido[2,3-d]pyrimidine, mp>250° C.; NMR (DMSO-d6, 80 MHz) d 2.28 and 2.30(brs, 3H), 6.77 and 7.06(brs, 1H), 7.72(d, 2H, J=8.5 Hz), 7.97(d, 2H, J=8.5 Hz), 8.27(d, 1H, J=2.0 Hz), 8.72(d, 1H, J=2.0 Hz).

Sources & evidence

ORD record
ord-4a4493696abe45659cc3690b8a1a05b3
Source dataset
uspto-grants-1991_06
Patent number
US05026851

Reaction notes

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