反应详情

Four solutions were prepared by dissolving 11.8 g (0.10 mol) of 2-pentylpropane-1,3-diol (prepared in Example 1 following the procedures of Steps 1-2), 14.2 g (0.10 mol) of 3,4-difluorobenzaldehyde, and 0.9 g (0.005 mol) of p-toluenesulfonic acid in methylene chloride (b.p. 40° C.), chloroform (b.p. 60° C.), benzene (b.p. 80° C.) and toluene (b.p. 111° C.), respectively. The solutions were treated following the procedures of Step 3 of Example 1 to yield mixtures of the cis and trans isomers of 5-pentyl-2-(3',4'-difluorophenyl)-1,3-dioxane. The yields of each mixture from its respective solvent and the ratio of the trans isomer to the cis isomer of each mixture are shown in Table 1.

1. customFour solutions were prepared
2. additionThe solutions were treated