2-Amino-1-(2-mercapto-2-methylpropylamino)benzene → HCID 9974411, compound

HRID 1494708Notes

Reaction equation

HRID 1494708 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][CH2:9][C:10]([SH:13])([CH3:12])[CH3:11].[CH:14]1([CH2:17][S:18][C:19]([CH3:23])([CH3:22])[CH:20]=O)[CH2:16][CH2:15]1>>[CH:14]1([CH2:17][S:18][C:19]([CH3:23])([CH3:22])[CH2:20][NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[NH:8][CH2:9][C:10]([SH:13])([CH3:11])[CH3:12])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 100129272-Amino-1-(2-mercapto-2-methylpropylamino)benzeneHCID 10329544HCID 10329544, compound

Product 1

HCID 9974411HCID 9974411, compoundYield 85%

Procedure

2-Amino-1-(2-mercapto-2-methylpropylamino)benzene (0.43 g, 2.19×10-3 mol) and 0.82 g (5.19×10-3 mol, 237 M %) 2-cyclopropylmethylthio-2-methylpropanal were reacted by the method of Example 2 to yield 0.63 g (85%) of 1-(2-cyclopropylmethylthio-2-methylpropylamino)-2-(2-mercapto-2-methylpropylamino)benzene as an oily product after purification by filtration through flash silica in a 350 ml sintered glass funnel, eluting with 200 ml portions of 2×100% hexane, 3×90% hexane/ether, 2×80% hexane/ether.

Sources & evidence

ORD record
ord-88766883ee8c4ccabae32b6d287e80af
Source dataset
uspto-grants-1991_06
Patent number
US05026913

Reaction notes

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