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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1494744Generated: October 26, 2026

1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 7(4-Fluoro-2-isoindolinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

https://huagongshe.com/reaction/1494744

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 535414—
Reactant4-fluoro-2,3-dihydro-1H-isoindoleHCID 14795867—
SolventDimethylformamideHCID 6228—
Product7(4-Fluoro-2-isoindolinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 1479576666.1%

Reaction Steps

136 mg of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid, 206 mg of 4-fluoroisoindoline, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 127 mg of the target compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05026856
Source datasetuspto-grants-1991_06
ORD IDord-5934d2e864bc49cab0e69c775e6b2562
Source noteuspto-grants-1991_06