HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 7-[4-(t-Butyloxycarbonyl aminomethyl)-2-isoindolinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 535414 | — |
| Reactant | 4-(t-Butyloxycarbonylaminomethyl)isoindoline | HCID 19828489 | — |
| Product | 7-[4-(t-Butyloxycarbonyl aminomethyl)-2-isoindolinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 19828492 | — |
Reaction Steps
283 mg of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 300 mg of 4-(t-butyloxycarbonylaminomethyl)isoindoline, 300 mg of DBU, and 2 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 300 mg of 7-[4-(t-butyloxycarbonyl aminomethyl)-2-isoindolinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-731433415392412b894989874a27e53f |
| Source note | uspto-grants-1991_06 |