HRID1494810

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：O=C(O)c1cn(C2CC2)c2c(F)c(F)c(F)cc2c1=O

HCID535414

1-CYCLOPROPYL-6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

C13H8F3NO3

HCID19828489

Carbamic acid, [(2,3-dihydro-1H-isoindol-4-yl)methyl]-, 1,1-dimethylethyl ester

C14H20N2O2

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)C(N)c1cccc2c1CN(c1c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c1F)C2

HCID19828492

未命名化合物

PROCEDURE

实验过程

283 mg of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 300 mg of 4-(t-butyloxycarbonylaminomethyl)isoindoline, 300 mg of DBU, and 2 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 300 mg of 7-[4-(t-butyloxycarbonyl aminomethyl)-2-isoindolinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-731433415392412b894989874a27e53f
来源数据集: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05026856
来源说明: uspto-grants-1991_06

反应 SMILES

[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:3][CH2:2]1.[C:21]([O:25][C:26](NCC1C=CC=C2C=1CNC2)=[O:27])([CH3:24])([CH3:23])[CH3:22].[CH2:39]1[CH2:49][CH2:48][N:47]2C(=N[CH2:44][CH2:45][CH2:46]2)[CH2:41][CH2:40]1.[CH3:50][N:51](C=O)C>>[C:21]([O:25][C:26]([CH:50]([NH2:51])[C:39]1[CH:40]=[CH:41][CH:44]=[C:45]2[C:49]=1[CH2:48][N:47]([C:11]1[C:12]([F:14])=[C:13]3[C:8]([C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5][N:4]3[CH:1]3[CH2:3][CH2:2]3)=[CH:9][C:10]=1[F:16])[CH2:46]2)=[O:27])([CH3:22])([CH3:23])[CH3:24]