HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 5-Fluoro-2,3-dihydro-1H-isoindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | 2-(p-Toluenesulfonyl)-5-fluoroisoindoline | HCID 15167895 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 5-Fluoro-2,3-dihydro-1H-isoindole | HCID 14795869 | 0.1% |
Reaction Steps
The procedure of Reference Example 6-(3) was followed using 10.2 g of 2-(p-toluenesulfonyl)-5-fluoroisoindoline, 10 g of phenol, 150 ml of 48% hydrobromic acid, and 25 ml of propionic acid. Purification of the crude product by vacuum distillation gave 5.0 mg of 5-fluoroisoindoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-2fbf56063a0940459b2e1d536676d31f |
| Source note | uspto-grants-1991_06 |