HRID1494837

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID996

Phenol

C6H6O

HCID1032

未命名化合物

HCID15167895

5-Fluoro-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-1H-isoindole

C15H14FNO2S

PRODUCTS

生成物

HCID14795869

5-Fluoro-2,3-dihydro-1H-isoindole

C8H8FN

收率 0.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID260

Hydrogen Bromide

BrH

PROCEDURE

实验过程

The procedure of Reference Example 6-(3) was followed using 10.2 g of 2-(p-toluenesulfonyl)-5-fluoroisoindoline, 10 g of phenol, 150 ml of 48% hydrobromic acid, and 25 ml of propionic acid. Purification of the crude product by vacuum distillation gave 5.0 mg of 5-fluoroisoindoline.

WORKUP

后处理

customPurification of the crude product
distillationby vacuum distillation