HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4-bromo-2,3-dihydro-1H-isoindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | 4-Bromo-2-tosylisoindoline | HCID 15167897 | — |
| Solvent | Propionic Acid | HCID 1032 | — |
| Product | 4-bromo-2,3-dihydro-1H-isoindole | HCID 14795870 | 92.5% |
Reaction Steps
The procedure of Reference Example 6-(3) was followed using 9.61 g of 2-(p-toluenesulfonyl)-4-bromoisoindoline, 10 g of phenol, 120 ml of 48% hydrobromic acid, and 20 ml of propionic acid. Purification of the crude product by vacuum distillation gave 5.0 g of 4-bromoisoindoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-823fc84af3f249209d928ad8ba93a319 |
| Source note | uspto-grants-1991_06 |