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HRID1494838

反应详情

EQUATION

反应方程式

HRID 1494838 的结构方程式

REACTANTS

反应物

3
结构：Br
HCID260

Hydrogen Bromide

BrH

结构：Oc1ccccc1
HCID996

Phenol

C6H6O

结构：Cc1ccc(S(=O)(=O)N2Cc3cccc(Br)c3C2)cc1
HCID15167897

未命名化合物

PRODUCTS

生成物

1
结构：Brc1cccc2c1CNC2
HCID14795870

4-Bromo-2,3-dihydro-1H-isoindole

C8H8BrN

收率 92.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCC(=O)O
溶剂HCID1032

未命名化合物

PROCEDURE

实验过程

The procedure of Reference Example 6-(3) was followed using 9.61 g of 2-(p-toluenesulfonyl)-4-bromoisoindoline, 10 g of phenol, 120 ml of 48% hydrobromic acid, and 20 ml of propionic acid. Purification of the crude product by vacuum distillation gave 5.0 g of 4-bromoisoindoline.

WORKUP

后处理

  1. customPurification of the crude product
  2. distillationby vacuum distillation