Hydrogen Bromide → 4-Nitroisoindoline hydrobromide

HRID 1494841Notes

Reaction equation

HRID 1494841 reaction equation
C(OC([N:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N+:15]([O-:17])=[O:16])[CH2:7]1)=O)C.[BrH:18]>C(O)(=O)C>[BrH:18].[N+:15]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:13]=1[CH2:14][NH:6][CH2:7]2)([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 198284912-Ethoxycarbonyl-4-nitroisoindoline

Product 1

HCID 198284974-Nitroisoindoline hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

2.36 g of 2-ethoxycarbonyl-4-nitroisoindoline was added to 70 ml of 25% hydrobromic acid in acetic acid. The mixture was stirred for 20 hours at 100° C., concentrated under reduced pressure, and recrystallized from ethanol to give 2.11 g of 4-nitroisoindoline hydrobromide.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-1f044a69168b486bab633bec9723a227
Source dataset
uspto-grants-1991_06
Patent number
US05026856

Reaction notes

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