反应详情

3.03 g of 2-ethoxycarbonyl-4-hydroxymethylisoindoline and 2.91 g of potassium hydroxide were dissolved in a mixture of 25 ml isopropyl alcohol and 2.5 ml of water. The mixture was heated under refluxing for 3 days. After the addition of water, the resulting reaction mixture was extracted with chloroform. The extract was washed with brine, concentrated, and recrystallized from carbontetrachloride to give 1.48 g of 4-hydroxymethylisoindoline.

1. temperatureThe mixture was heated
2. temperatureunder refluxing for 3 days
3. customthe resulting reaction mixture
4. extractionwas extracted with chloroform
5. washThe extract was washed with brine
6. concentrationconcentrated
7. customrecrystallized from carbontetrachloride