Dichloromethane → 3-(3-Chloro-5-fluorophenyl)azetidin-3-ol

HRID 149597Notes

Reaction equation

HRID 149597 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([C:9]2([OH:20])[CH2:10][N:11]([C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[CH2:12]2)[cH:5][c:6]([F:8])[cH:7]1.[Cl:28][CH2:29][Cl:30].[OH:21][C:22]([C:23]([F:24])([F:25])[F:26])=[O:27]>>[Cl:1][c:2]1[cH:3][c:4]([C:9]2([OH:20])[CH2:10][NH:11][CH2:12]2)[cH:5][c:6]([F:8])[cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66995489Tert-butyl 3-(3-chloro-5-fluorophenyl)-3-hydroxyazetidine-1-carboxylate

Product 1

HCID 669953933-(3-Chloro-5-fluorophenyl)azetidin-3-ol

Sources & evidence

ORD record
ord-014872ca2ddf4a819ebf283c9ef1968e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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