Hydrazine hydrate (1:1) → HCID 178502067, compound

HRID 1496644Notes

Reaction equation

HRID 1496644 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]=[CH:10][N:11](C)C)=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[O:18][CH3:19].O.[NH2:22]N>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][NH:11][N:22]=2)=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[O:18][CH3:19]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66789975methyl N-[[2-chloro-5-[3-(dimethylamino)-1-oxo-2-propen-1-yl]phenyl]methyl]carbamate2×

Product 1

HCID 178502067HCID 178502067, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl N-[[2-chloro-5-[3-(dimethylamino)-1-oxo-2-propen-1-yl]phenyl]methyl]carbamate (i.e. the product of Step A) (4.14 g, 13.9 mmol) in methanol (80 mL) was added hydrazine hydrate (0.771 g, 15.4 mmol). The reaction mixture was stirred at room temperature for 2 days. The reaction mixture was filtered and the solid collected was dried under reduced pressure to provide the title compound, a compound of the present invention, as a solid (3.26 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe solid collected
  3. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-d2c6227684bf4edea1dc63c49057823b
Source dataset
uspto-grants-2015_12
Patent number
US09198433B2

Reaction notes

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