HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1496853Generated: October 30, 2026
Methyl iodide → 7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one
https://huagongshe.com/reaction/1496853
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 7-Bromo-3,4-dihydroquinazolin-4-one | HCID 135555612 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one | HCID 58574514 | — |
Reaction Steps
400 mg 7-Bromoquinazolin-4(3H)-one was dissolved in DMF and 720 mg of CsCO3 and 130 μL of methyliodide were added and the mixture stirred for 3 h at 25° C. Additional 50 μL methyliodide were added and stirred overnight at 25° C. The mixture was filtered off and the mother liquor diluted with DCM and extracted with water. The solvent was removed to yield 490 mg of 7-bromo-3-methylquinazolin-4(3H)-one as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09199937B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-168871d7a6094b93b910d797bb03ca6c |
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| Source note | uspto-grants-2015_12 |
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